Articure Losartan Potassium 50 mg Film-Coated Tablet Sold by 10 Pieces for Hypertension Management and Nephroprotection

IMPORTANT NOTICE (Rx): This product is classified as a Prescription-Only Medicine (Rx) in the Philippines. It is a targeted cardiovascular angiotensin II receptor blocker (ARB) that must strictly be purchased and taken under the direct clinical diagnosis, monitoring, and prescription of a licensed physician. Regular blood pressure tracking and periodic renal function monitoring are recommended.

Articure Losartan Potassium 50 mg Film-Coated Tablet (Targeted Cardiovascular Therapy & Blood Pressure Maintenance Care Sold by blister pack of 10 pieces) is an essential oral formulation prescribed for the management of hypertension and for providing nephroprotection in patients with type 2 diabetes and hypertension.

• Packaging & Quantity: Sold by blister pack of 10 pieces (1 sealed foil blister strip of 10 tablets). Each film-coated tablet provides 50 mg Losartan Potassium.

• Targeted Angiotensin II Receptor Blockade: Selectively blocks the binding of angiotensin II to the $AT_1$ receptor in vascular smooth muscle and the adrenal gland, promoting systemic vasodilation and decreasing peripheral vascular resistance without causing the persistent dry cough commonly linked to ACE inhibitors.

Targeted Clinical Indications:

• Long-term maintenance and management of primary essential hypertension.

• Reduction of cardiovascular morbidity and mortality (including stroke risk) in hypertensive patients with left ventricular hypertrophy.

• Renal protection in patients with type 2 diabetes accompanied by proteinuria and hypertension.

Directions for Use: Swallow the tablet whole with a glass of water, with or without meals:

• Standard Adult Maintenance Dose: 50 mg (1 tablet) once daily, or strictly as adjusted and directed by your physician (some individuals may require up to 100 mg daily).

• Take at the same time each day to maintain steady blood pressure levels.

• Safety Precautions & Warnings: Contraindicated during pregnancy (drugs acting on the renin-angiotensin system can cause serious fetal harm or death when used during the second and third trimesters). Avoid combining with potassium supplements or potassium-sparing diuretics unless closely supervised by a doctor, due to the risk of hyperkalemia. Discontinue immediately and seek urgent medical evaluation if facial swelling, severe dizziness, lightheadedness, or sudden reduction in urine output occurs.

• Storage Guidance: Store at temperatures not exceeding 30°C in a dry place protected from excessive heat, moisture, and direct sunlight. Keep the blister pack intact until use and securely out of reach of children.

FDA Registration No.: DRP-13687-02